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Selenium and Lymphedema - from biosyn

Selenium for treating lymphedemas

Until now, it has unfortunately been almost impossible to successfully treat lymphedemas with medication. The only scientifically proven exception is sodium selenite, an inorganic form of the trace element selenium.1

What is selenium?

Selenium is a vital trace element that must be taken as part of the daily diet. It is necessary for numerous metabolic processes in the body. One of the most important properties of selenium as antioxidative substance is the protection it provides from free oxygen radicals. In addition, it also plays a significant role in the immune system and in regulating inflammatory processes.

Due to the low selenium content in German food, the average selenium level of the German population is relatively low.2, 3 Since the selenium requirement frequently increases in patients with chronic diseases, in many cases a selenium deficiency can develop. Findings from a recent trial showed, for instance, that almost 80% of people with advanced lymphedema (stage III) suffer from selenium deficiency.4

What is the effect of sodium selenite on lymphedema?

Sodium selenite acts as an antioxidant and has an anti-inflammatory effect. On the one hand it promotes volume reduction by lymphatic drainage and on the other hand it protects from inflammations in the affected extremities. Simultaneously, sodium selenite increases the activity of important selenoproteins that strengthen the immune system.4

Inorganic or organic selenium?

Selenium basically occurs in two forms: inorganic and organic. The most frequently found inorganic form of selenium is sodium selenite. The most widely spread organic form is selenomethionine.3, 5 Inorganic forms such as sodium selenite are better suited to correct a selenium deficiency, since they are rapidly absorbed by the body and can be specifically incorporated into selenoproteins. Organic forms of selenium can be mistaken by the body for sulfur-containing compounds, and therefore be non-specifically incorporated into proteins. Moreover, the body is able to eliminate excess sodium selenite via urine without any difficulty, so that it does not accumulate in the blood above the natural requirement.5, 6

biosyn – manufacturer of selenase®

Founded in 1984, biosyn Arzneimittel GmbH is one of the first German biotech companies, with currently about 70 employees in Germany and subsidiaries in Liechtenstein, Austria, and the USA. Its product line comprises about 30 different products, ranging from biotechnologically manufactured medications to chemotherapeutics, complementary drugs and nutritional supplements, with emphasis on intensive care medicine and oncology. The patient as an entire human being is consistently the focus of attention. More information at www.biosyn.de.

Would you like to receive additional information about selenium and the immune system on a regular basis? If so, then please register for the biosyn newsletter   immuNews.

Literature:

1. Paskett ED, Dean JA, Oliveri JM et al. Cancer-related lymphedema risk factors, diagnosis, treatment, and impact: a review. J Clin Oncol 2012; 30: 3726-3733
2. Anke, M. et al. (1999) Trace element intake and balance in adults in Central Europe. Trace Elements in Man and Animals 10, Proceedings of the International Symposium on Trace Elements in Man and Animals, 10th, Evian, France. 2000, 209-14.
3. Bundesgesundheitsblatt – Selen in der Umweltmedizin (2006). Online verfügbar unter: http://edoc.rki.de/documents/rki_ab/re67flHRghoUo/PDF/2569lt94O6HF.pdf (Zuletzt eingesehen am 21.07.2017).
4. Pfister C, Dawzcynski H, Schingale FJ. Sodium selenite and cancer related lymphedema: Biological and pharmacological effects. J Trace Elem Med Biol 2016; 37: 111-116
5. Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008; 4: 89-96
6. European Food Safety Authority. Tolerable upper intake levels for vitamins and minerals, February 2006. Online available at: http://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf (last consulted on 07 Sept. 2017).

selenase®

Active substance: Sodium selenite pentahydrate
selenase® 100 µg pro injectione, selenase® T pro injectione, selenase® 100 µg peroral, selenase® T peroral, selenase® 50 peroral: 50 µg selenium per ml
selenase® 50 AP: 50 µg selenium per tablet
selenase® RP Tabletten: 79 µg selenium per tablet
selenase® 300 RP: 300 µg selenium per tablet

biosyn Arzneimittel GmbH
Schorndorfer Strasse 32
70734 Fellbach
Germany
Tel. + 49 711 575 32 00
Fax + 49 711 575 32 99
E-Mail: info@biosyn.de
http://www.biosyn.de

Indications:

selenase® 100 µg pro injectione, selenase® T pro injectione, selenase® 100 µg peroral, selenase® T peroral:
Proven selenium deficiency that cannot be offset from food sources. Selenium deficiencies may occur as a result of states of maldigestion and malabsorption, as well as in malnutrition (e.g. due to complete parenteral nutrition).
selenase® 50 peroral, selenase® 50 AP, selenase® RP Tabletten, selenase® 300 RP:
Proven selenium deficiency that cannot be offset from food sources. Selenium deficiencies may occur as a result of states of maldigestion and malabsorption, as well as in malnutrition

Composition:

selenase® 100 µg pro injectione: 1 ampoule of 2 ml solution for injection contains: 0.333 mg sodium selenite pentahydrate, corresponding to 100 µg (micrograms) selenium.
selenase® T pro injectione: 1 injection vial of 10 ml / 20 ml solution for injection contains: 1.67 mg / 3.33 mg sodium selenite pentahydrate, corresponding to 500 µg / 1000 µg (micrograms) selenium.
selenase® 100 µg peroral: 1 drinking ampoule of 2 ml oral solution contains: 0.333 mg sodium selenite pentahydrate, corresponding to 100 µg (micrograms) selenium.
selenase® T peroral: 1 ml oral solution contains: 0.167 mg sodium selenite pentahydrate, corresponding to 50 µg (micrograms) selenium.
selenase® 50 peroral: 1 drinking ampoule of 1 ml oral solution contains: 50 µg pure selenium as sodium selenite pentahydrate in a 0.9 % NaCl-solution.
Excipients: Sodium chloride, hydrochloric acid, water for injections.
selenase® 50 AP: 1 tablet contains 0.167 mg sodium selenite pentahydrate (corresponding to 50 µ[mikro]g selenium). Excipients: gelatin, magnesium stearate (Ph. Eur.), maize starch, sucrose, talcum.
selenase® 300 RP: 1 tablet contains 0.999 mg sodium selenite pentahydrate (corresponding to 300 µg selenium). Excipients: magnesium stearate (Ph. Eur.), maize starch, povidone K25, sucrose, talcum.
selenase® RP Tabletten: 1 tablet contains 263 µg of sodium selenite pentahydrate (corresponding to 1 µ[micro]mol = 79 µg of selenium). Excipients: Microcrystalline cellulose, sorbitol (Ph. Eur.), povidone K25, magnesium stearate (Ph. Eur.), palmitic and stearic acid.

Contra-indications: Selenium poisoning.

Undesirable effects:

None known to date if the medicinal product is administered according to prescription.
selenase® 100 µg pro injectione, selenase® T pro injectione
General disorders and administration site conditions:
Frequency not known (cannot be estimated from the available data):
After intramuscular administration local pain at the site of administration has been reported.

Form of administration, size of packages:

selenase® 100 µg pro injectione: 10 or 50 ampoules of 2 ml solution for injection.
selenase® T pro injectione: 2 or 10 injection vials of 10 ml solution for injection, hospital-size pack 30 (3 x 10) or 50 (5 x 10) injection vials of 10 ml solution for injection, 2 or 10 injection vials of 20 ml solution for injection, hospital-size pack 30 (3 x 10) or 50 (5 x 10) injection vials of 20 ml solution for injection.
selenase® 100 µg peroral: 20, 60, 90 or 100 ampoules of 2 ml oral solution.
selenase® T peroral: 10 drinking bottles of 10 ml oral solution plus one measuring cup.
selenase® 50 peroral: 50 drinking ampoules of 1 ml oral solution.
selenase® 50 AP: 20 tablets, 50 tablets, 100 tablets.
selenase® 300 RP: 20 tablets, 50 tablets, 100 tablets.
selenase® RP Tabletten: 50 tablets, 100 tablets.

selenase® 100 µg pro injectione, selenase® T pro injectione, selenase® 100 µg peroral, selenase® T peroral,
selenase® 300 RP, selenase® RP Tabletten:

Subject to prescription

selenase® 50 peroral, selenase® 50 AP:

Subject to sale in pharmacies
01/17 e

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